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Caleb Rhys O'Brien - Journal

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Posted 2023-08-20T02:48:25Z

Caleb Rhys O’Brien Update - 8/19/23

Hi All, 

We are truly devastated to have to write this update. On Wednesday 8/9 after Caleb’s routine bloodwork, we found out that Caleb’s CAR-T treatment was starting to “wear off”.  This is not ideal, because the goal is to make it at least 1 year out from the infusion with the CAR-T working as it should.  He had only just passed the 7 month mark.  After a bone marrow biopsy this past week, we received the news that his cancer has come back.  There is technically less than 0.01% leukemia in his marrow right now, but this is unfortunately still considered a relapse. After speaking to his team of doctors on Thursday, the plan now is to re-infuse him with a second round of CAR-T in the next 2 weeks.  They will then do another bone marrow biopsy in a month to make sure that he is back in full remission, and we will then move immediately into Bone Marrow Transplant in October. The reason that they plan to re-infuse the CAR-T is that he needs to be in complete remission again to move forward with the transplant.  [...]